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16세기 조선, 내의원 의관 최원은 세자 이호를 독살하려 했다는 누명을 쓰고 목숨을 잃을 위기에 처하지만, 처형 직전 구사일생으로 탈옥에 성공하다. 시시각각 그를 쫓는 추적자들을 피해다니며 구차한 목숨을 끝내 지키려는 건, 불치병을 앓는 딸 때문이다. 그의 목표는 더 늦기 전에 딸의 곁으로 돌아가는 것이지만, 의도치 않게 권력 싸움에 휘말리면서 누명을 벗는 길은 쉽지 않아보인다.

In the 16th century Joseon, Choi Won, the doctor of the Royal Medical Institute, was framed for poisoning crown prince Lee Ho. He broke out of prison just before the execution and ran away from chasers. The only reason he had to stay alive was to go back to his only daughter, who was suffering from an incurable disease. But trying to clear his name is not as easy as he expected since the incident he got involved in is another front of the Royal power struggle.

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